Tumori is an international journal devoted to the publication of original articles on experimental and clinical cancer research. Editorial and review articles will normally be invited by the Editors. Unsolicited review articles will also be considered and will be reviewed as original articles. Manuscripts are accepted for review with the understanding that the same work has not been and will not be published nor is currently submitted elsewhere, and that all persons listed as authors have given their approval for the submission of the paper (this must be specified in a cover letter). Three copies of the manuscript, which must be written in clear, concise English and double-spaced throughout, must be sent to the Editorial Office of Tumori, Via G. Venezian 1, 20133 Milan (Italy), together with an electronic version (a 3.5” floppy disc or a CD-ROM containing text, figures and tables in MS Word or a MS Officecompatible format) and a cover letter. Manuscripts may also be submitted by e-mail to the editorial office at tumori@istitutotumori.mi.it. All pages of the manuscript must be numbered consecutively. Authors are invited to suggest competent reviewers in their fields.

Page 1 (title page) should include: a brief title (abbreviations and chemical formulas are not accepted); authors’ full names; academic or professional affiliations and addresses; a running title that should not exceed 50 characters including spaces; acknowledgments; complete address of the author to whom correspondence should be addressed, phone and fax number, e-mail address.

Page 2 should contain a short abstract (less than 300 words), which should be organized according to the following headings: 1. Aims and background; 2. Methods (or study design); 3. Results, and 4. Conclusions. This format is not required for short communications and case reports. A list of three or four key words that convey the meaning of the paper as a whole must be included.

The paper should be organized in the following format: Introduction, Material (or Patients) and Methods, Results, Discussion.

Tables and Figures must be cited consecutively in the text, using Arabic numerals. Each table should be titled, appropriately numbered and placed on a separate page. Units of measurement should be indicated and all abbreviations defined. All the illustrations (graphs, drawings and photographs) should be referred to in the text as Figures. Photographs should be either good quality glossy prints or (in the case of manuscript submission by e-mail) high-resolution electronic files; in the latter case, please send files in a zipped folder. Since graphs are generally reduced in size to 8.5 cm, numbers, letters and symbols are to be originally large enough so that, when reduced, they will remain at least 2 mm high to maintain legibility. To avoid reduction, the width of photographs should generally not exceed 8.5 cm. When necessary, photographs can be arranged to form a plate of the maximum size of 17 cm (width) x 18 cm (height). Figure legends should be typed on a separate page.

References should be listed at the end of the paper and should be numbered consecutively as they are cited. In the text, references are identified by Arabic numerals in superscript. References first cited in tables or figure legends must be numbered in such a way as to be in sequence with references cited in the text. References should include the names of all authors (last name followed by initials without full stop; don’t use et al.); full title of the article; name of the journal abbreviated according to the style of Index Medicus; volume number; first and last page numbers; and year of publication. References to books should be written as follows: names of all authors; title of chapter. In: title of the book, editor(s), pages, publisher, place, year. For electronic material, please refer to the instructions of the National Library of Medicine (www.nlm.nih.gov/citingmedicine/).

For example of correct style in manuscript preparation, please consult a recent issue of the journal.Manuscripts that are not adequately prepared will be returned to the authors for modification.

Reprints can be ordered when returning the revised page proofs and will be charged to the authors.